Which herbal supplement is known to interact with antidepressants?

St. John's Wort is well-known for its ability to interact with antidepressants. It is commonly used as a herbal remedy for mild to moderate depression. The active compounds in St. John's Wort, particularly hypericin and hyperforin, can influence the metabolism of various medications by affecting cytochrome P450 enzymes in the liver, which are crucial for drug metabolism. This interaction can lead to reduced efficacy of certain antidepressants, especially selective serotonin reuptake inhibitors (SSRIs), potentially leading patients to experience inadequate relief from depressive symptoms.

Other herbal supplements like ginseng, echinacea, and turmeric do not exhibit the same level of interaction with antidepressant medications. While they may have other effects or benefits, their interaction with antidepressants is not as pronounced or significant as that of St. John's Wort. Understanding this relationship is crucial for healthcare providers when recommending herbal supplements to patients who are also on antidepressant therapy, ensuring safe and effective management of their mental health.