What is an example of a drug that alters olfaction?

Streptomycin is known to have the potential to alter olfaction because it is an antibiotic that can affect the central nervous system and, particularly in cases of high dosages or prolonged use, has been associated with various sensory deficits including changes in taste and smell. The mechanism is not entirely understood, but it is believed that streptomycin may have neurotoxic effects that impact the olfactory pathways or receptors involved in the sense of smell.

The other options do not have a noted impact on olfaction in a similar way. Aspirin is primarily used as an anti-inflammatory and pain reliever without significant effects on smell. Lisinopril, an antihypertensive medication, is not associated with alterations in the olfactory system, and simvastatin, used for lowering cholesterol, also does not have documented effects on olfactory function. Thus, streptomycin stands out as a medication that can reasonably be linked to changes in the sense of smell.